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Problem :

I am currently working with arduino nano and facing following error 
avrdude: ser_open(): can't open device "\\.\com1": the system cannot find the file specified.
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1 Answer

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Solution :

This is how I solved the problem i faced in recent past. You will find the Arduino COM port in device manager as shown below:

enter image description here

Now you need to go to the Advance properties of the port

enter image description here

Please set your COM port number to COM1

enter image description here

Then replug the USB.

After all above steps your issue will be resolved.

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